Surbek D V, Glanzmann R, Nars P W, Holzgreve W
Department of Obstetrics and Gynecology, University Hospital, Basel, Switzerland.
J Perinat Med. 1998;26(3):240-3.
Successful pregnancies in patients with transfusion-dependent homozygous beta-thalassemia major are rare. We report the course of a pregnancy and newborn data during lactation and desferrioxamine therapy in the mother. The twin-pregnancy was complicated by preeclampsia. Besides normal iron level in breast milk, no clinical or hematological abnormalities due to desferrioxamine therapy could be shown in the newborns. Our observation suggests that chelating therapy during lactation does not alter iron excretion in breast milk or iron metabolism in offsprings. Breast feeding in newborns from patients with thalassemia major and desferrioxamine therapy seems justified.
对于依赖输血的重型纯合子β地中海贫血患者而言，成功妊娠极为罕见。我们报告了一位母亲在哺乳期及接受去铁胺治疗期间的妊娠过程及新生儿数据。此次双胎妊娠并发了先兆子痫。母乳中铁水平正常，且未发现新生儿因去铁胺治疗出现任何临床或血液学异常。我们的观察表明，哺乳期的螯合疗法不会改变母乳中的铁排泄或后代的铁代谢。对于重型地中海贫血患者且接受去铁胺治疗的母亲所生新生儿，母乳喂养似乎是合理的。
