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Differentiation of lysine/glutamine in peptide sequence analysis by electrospray ionization sequential mass spectrometry coupled with a quadrupole ion trap.

作者信息

Bahr U, Karas M, Kellner R

机构信息

Division for Instrumental Analytical Chemistry, J. W. Goethe University, Frankfurt, Germany.

出版信息

Rapid Commun Mass Spectrom. 1998;12(19):1382-8. doi: 10.1002/(SICI)1097-0231(19981015)12:19<1382::AID-RCM327>3.0.CO;2-J.

DOI:10.1002/(SICI)1097-0231(19981015)12:19<1382::AID-RCM327>3.0.CO;2-J
PMID:9773523
Abstract

Electrospray ionization coupled to a quadrupole ion trap mass spectrometer is used to differentiate between the isobaric amino acids lysine and glutamine in sequence analysis of peptides. Collision-induced dissociation is used for fragmentation. Several isobaric peptides with one or more lysines or glutamines at different positions were investigated. The ambiguous amino acid either in the peptide chain or at the C- or N-terminus can be clearly identified based on specific side chain fragment ions resulting from MS3 or MS4 of B- and Y"-fragment ions.

摘要

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