Costa M A, Sousa O, Azevedo I, Castro C, Fernandes T, Vieira E
Departamento de Radioterapia, Instituto Português de Oncologia Francisco Gentil, Porto.
Acta Med Port. 1998 Jun;11(6):539-42.
Medullary carcinoma of the thyroid represents 3 to 10% of all thyroid cancers. Surgery is the main treatment. External beam radiotherapy has a fundamental role in the treatment of residual disease following surgery, in cases of cervical node involvement, and in unresectable tumors. Between 1975 and 1993, 12 patients with medullary carcinoma of the thyroid were treated at the Department of Radiotherapy of the Portuguese Institute of Oncology in Oporto. Nine of these patients (75%) were male and 3 (25%) female, ranging from 24 to 80 years of age (mean = 43). All of them had residual tumor after surgery and underwent treatment with external beam radiotherapy. The follow-up period ranged from 36 to 180 months, with a median of 78 months; 8 patients (66.7%) are alive, 5 of them show no evidence of disease. Average survival was 70 months, and 4 patients (33%) died with metastatic disease. The aim of this paper is to analyse the role of external beam radiotherapy in local control of these tumors, with a brief review of the literature.
甲状腺髓样癌占所有甲状腺癌的3%至10%。手术是主要治疗方法。外照射放疗在手术后残留疾病的治疗、颈部淋巴结受累病例以及不可切除肿瘤的治疗中起着重要作用。1975年至1993年间，12例甲状腺髓样癌患者在波尔图葡萄牙肿瘤研究所放疗科接受治疗。其中9例（75%）为男性，3例（25%）为女性，年龄在24岁至80岁之间（平均43岁）。他们均在手术后有残留肿瘤，并接受了外照射放疗。随访期为36至180个月，中位数为78个月；8例（66.7%）存活，其中5例无疾病证据。平均生存期为70个月，4例（33%）死于转移性疾病。本文旨在分析外照射放疗在这些肿瘤局部控制中的作用，并对文献进行简要综述。
