Yoshimoto H, Yano H, Kobayashi K, Hirano A, Motomura K, Ohtsuru A, Yamashita S, Fujii T
Department of Plastic and Reconstructive Surgery, Atomic Bomb Disease Institute at the Nagasaki University School of Medicine, Sakamoto, Japan.
Plast Reconstr Surg. 1998 Oct;102(5):1605-10. doi: 10.1097/00006534-199810000-00041.
Congenital hemifacial hypertrophy is expressed in facial asymmetry resulting from unilateral overgrowth. We examined proliferative activity of primary cultured osteoblasts taken from the hemifacial hypertrophic side of an 18-year-old woman compared with the normal side. Both fetal calf serum and basic fibroblast growth factor stimulated osteoblast DNA synthesis, and cultured osteoblast proliferation was markedly increased in the hypertrophic side. Neutralizing antibody against basic fibroblast growth factor was effective to partially block fetal calf serum-induced DNA synthesis. These results suggest that fibroblast growth factor and its receptor signal transduction axis may be selectively involved in affected osteoblasts, leading to progression of congenital hemifacial hypertrophy.
先天性半侧颜面肥大表现为单侧过度生长导致的面部不对称。我们检测了一名18岁女性半侧颜面肥大侧原代培养成骨细胞的增殖活性，并与正常侧进行比较。胎牛血清和碱性成纤维细胞生长因子均刺激成骨细胞DNA合成，且肥大侧培养的成骨细胞增殖明显增加。针对碱性成纤维细胞生长因子的中和抗体可有效部分阻断胎牛血清诱导的DNA合成。这些结果表明，成纤维细胞生长因子及其受体信号转导轴可能选择性地参与受累成骨细胞，导致先天性半侧颜面肥大的进展。
