Randolph G J, Beaulieu S, Lebecque S, Steinman R M, Muller W A
Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C-420, New York, NY 10021, USA.
Science. 1998 Oct 16;282(5388):480-3. doi: 10.1126/science.282.5388.480.
Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration.
对于抗原呈递细胞的树突状细胞系统而言，游走于传入淋巴管进入淋巴结并在其中启动免疫反应的面纱样树突状细胞至关重要。20年前发现的面纱样细胞的起源尚不清楚。与内皮细胞共培养的单核细胞在2天内分化为树突状细胞，尤其是在吞噬内皮下胶原中的颗粒后。这些新生的树突状细胞沿从无腔面到有腔面的方向穿过内皮，就像进入淋巴管时那样。留在内皮下基质中的单核细胞则变成巨噬细胞。因此，单核细胞有两种与不同迁移模式相关的潜在命运。
