幼年雌性巴西日圆线虫产生一种经二甲基氨基乙醇高度修饰的排泄/分泌抗原（Juv-p120）。
Juvenile female Litomosoides sigmodontis produce an excretory/secretory antigen (Juv-p120) highly modified with dimethylaminoethanol.
作者信息
Hintz M, Schares G, Taubert A, Geyer R, Zahner H, Stirm S, Conraths F J
机构信息
Biochemisches Institut am Klinikum, Justus-Leibig-Universität, Giessen, Germany.
出版信息
Parasitology. 1998 Sep;117 ( Pt 3):265-71. doi: 10.1017/s0031182098002996.
A 120 kDa antigen produced by juvenile female Litomosoides sigmodontis (Juv-p120) was isolated and purified. The amino acid composition of the molecule was determined. Juv-p120 was shown to be highly modified with N,N-dimethyl-aminoethanol (28.4 mol%). Treatment of Juv-p120 with potassium hydroxide (beta-elimination) or with sodium m-periodate leads to the destruction of epitopes recognized by antibodies immune affinity-purified with isolated Juv-p120. Juvenile L. sigmodontis were shown to release Juv-p120 into the pleural cavity of infected Mastomys coucha before the onset of patency.
从感染的雌性幼年巴西日圆线虫（Litomosoides sigmodontis）中分离并纯化出一种120 kDa的抗原（幼年p120）。测定了该分子的氨基酸组成。结果显示，幼年p120被N，N-二甲基氨基乙醇高度修饰（28.4摩尔%）。用氢氧化钾（β-消除法）或间高碘酸钠处理幼年p120会导致被用分离出的幼年p120免疫亲和纯化的抗体识别的表位遭到破坏。结果表明，在感染的多乳鼠（Mastomys coucha）开放期开始之前，幼年巴西日圆线虫会将幼年p120释放到其胸腔中。
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