Takasaki T, Higashikawa M, Motoyama S, Sugita K, Kurane I
Department of Microbiology, Kinki University School of Medicine, Osaka, Japan.
J Laryngol Otol. 1998 Jul;112(7):617-21. doi: 10.1017/s0022215100141271.
The aetiology of idiopathic facial nerve palsy (Bell's palsy) and sudden deafness are not known, although viruses have been suspected as a cause of them. We investigated the relationship between Bell's palsy or sudden deafness, and reactivation of cytomegalovirus, human herpesvirus 6 (HHV-6) and 7 (HHV-7). Paired sera were collected from 22 patients with Bell's palsy and 24 patients with sudden deafness. IgG antibody titres to HHV-7 were increased in one patient with Bell's palsy. IgG antibody titres to HHV-6 were increased in one patient with Bell's palsy and two with sudden deafness. IgG antibody titres to cytomegalovirus were increased in one patient with sudden deafness. Titres of the three viral antibodies were not increased simultaneously in any patients. These viruses may contribute to the development of Bell's palsy or sudden deafness in some cases. It is, however, unlikely that these viruses are the main cause of Bell's palsy and sudden deafness in the majority of patients.
特发性面神经麻痹（贝尔氏麻痹）和突发性耳聋的病因尚不清楚，尽管病毒被怀疑是其病因。我们研究了贝尔氏麻痹或突发性耳聋与巨细胞病毒、人类疱疹病毒6型（HHV-6）和7型（HHV-7）再激活之间的关系。从22例贝尔氏麻痹患者和24例突发性耳聋患者中采集配对血清。1例贝尔氏麻痹患者的HHV-7 IgG抗体滴度升高。1例贝尔氏麻痹患者和2例突发性耳聋患者的HHV-6 IgG抗体滴度升高。1例突发性耳聋患者的巨细胞病毒IgG抗体滴度升高。在任何患者中，三种病毒抗体的滴度均未同时升高。在某些情况下，这些病毒可能促使贝尔氏麻痹或突发性耳聋的发生。然而，这些病毒不太可能是大多数患者贝尔氏麻痹和突发性耳聋的主要病因。
