Chu S M, Huang J L, Lin S J, Hsueh C
Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1998 Jul-Aug;39(4):268-70.
The treatment of Sjögren's syndrome (SS) is very controversial, though several therapeutic regimens have been proposed. Cyclophosphamide pulse therapy has been widely used in many disease entities. However, reports concerning its clinical application in SS were very rare. We report a 17-year-old girl presenting with lupus nephritis and SS, which was refractory to corticosteroid therapy but successfully treated with cyclophosphamide pulse therapy. The improvement of clinical features was confirmed by Schirmer's test and minor salivary gland biopsy.
干燥综合征（SS）的治疗颇具争议，尽管已有多种治疗方案被提出。环磷酰胺冲击疗法已广泛应用于多种疾病。然而，关于其在SS临床应用的报道却极为罕见。我们报告一例17岁患有狼疮性肾炎和SS的女孩，该患者对皮质类固醇治疗无效，但采用环磷酰胺冲击疗法后成功治愈。通过施墨试验和小唾液腺活检证实了临床症状的改善。
