Chan B S, Lazzaro V A, Seale J P, Duggin G G
Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Pharmacol Ther. 1998 Sep;79(3):193-203. doi: 10.1016/s0163-7258(98)00015-1.
Paraquat (PQ), a cationic herbicide, is predominantly excreted by the kidneys, but it is also nephrotoxic. It is thought to cause damage to proximal renal epithelial cells, which results in acute renal failure. The precise mechanism by which PQ is excreted by the kidney has not been fully elucidated, although current evidence indicates that it is actively secreted via a cation transport system. This review examines the renal cytotoxic effect and excretory mechanisms of PQ, and the role of organic cations in modulating the renal handling of PQ.
百草枯（PQ）是一种阳离子除草剂，主要通过肾脏排泄，但它也具有肾毒性。据认为，它会对近端肾上皮细胞造成损害，从而导致急性肾衰竭。尽管目前的证据表明PQ是通过阳离子转运系统被主动分泌的，但其通过肾脏排泄的确切机制尚未完全阐明。本文综述了PQ的肾细胞毒性作用和排泄机制，以及有机阳离子在调节肾脏对PQ处理中的作用。
