Misoph M, Schwender S, Babin-Ebell J
Department of Cardiothoracic Surgery, University Hospital, Würzburg, Germany.
Thorac Cardiovasc Surg. 1998 Aug;46(4):222-7. doi: 10.1055/s-2007-1010229.
Cardiopulmonary bypass (CPB) is associated with an activation of leukocytes. The extent of this activation was thought to depend on the applied CPB-circuit set-up. The present study comparatively evaluated the effect of roller pump, centrifugal pump, and uncoated and heparin-coated surfaces.
73 patients were included, randomly assigned to 3 groups. In group A a roller pump was used, in group B a centrifugal pump, and in group C a centrifugal pump together with Carmeda heparin-coated surfaces. The quantitative (cell count) and the qualitative changes of leukocyte populations (subpopulations and expression of the CD126-, HLA-DR-, CD45 RO-, CD71 antigens) was comparatively analysed before, during, and following CPB.
Groups A and B did not differ in leukocyte counts and the differences between groups B and C were restricted to single time points. Neither groups A and B, nor groups B and C differed significantly in the relative distribution of lymphocyte subpopulations or in the percentage of CD126+, HLA-DR+, CD45 RO+ and CD71+ leukocyte subpopulations.
CPB affects the cellular immune system; however, this effect seems to be a physiological reaction, independent of the applied CPB circuit system.
体外循环（CPB）与白细胞激活有关。这种激活的程度被认为取决于所应用的CPB回路设置。本研究比较评估了滚压泵、离心泵以及未涂层和肝素涂层表面的影响。
纳入73例患者，随机分为3组。A组使用滚压泵，B组使用离心泵，C组使用带有卡美达肝素涂层表面的离心泵。在CPB前、中、后对白细胞群体的定量（细胞计数）和定性变化（亚群以及CD126、HLA-DR、CD45 RO、CD71抗原的表达）进行了比较分析。
A组和B组的白细胞计数无差异，B组和C组之间的差异仅限于单个时间点。A组和B组之间、B组和C组之间在淋巴细胞亚群的相对分布或CD126 +、HLA-DR +、CD45 RO +和CD71 +白细胞亚群的百分比方面均无显著差异。
CPB会影响细胞免疫系统；然而，这种影响似乎是一种生理反应，与所应用的CPB回路系统无关。
