与大量安非他酮过量相关的心电图传导延迟。
ECG conduction delays associated with massive bupropion overdose.
作者信息
Paris P A, Saucier J R
机构信息
Department of Emergency Medicine, Maine Medical Center, Portland 04102, USA.
出版信息
J Toxicol Clin Toxicol. 1998;36(6):595-8. doi: 10.3109/15563659809028055.
BACKGROUND
Bupropion, a relatively new antidepressant, is highly regarded for its safety profile in therapeutic doses and in the overdose. Seizure is the primary adverse reaction associated with bupropion overdoses. Clinically significant cardiovascular complications are rare.
CASE REPORT
We report the case of an adult male who ingested 9 g bupropion and developed neurologic toxicity as well as intraventricular conduction disturbances on electrocardiogram. Cardiac monitoring of these patients should be considered.
背景
安非他酮是一种相对较新的抗抑郁药，因其治疗剂量及过量服用时的安全性备受关注。癫痫发作是安非他酮过量服用相关的主要不良反应。临床上显著的心血管并发症较为罕见。
病例报告
我们报告一例成年男性病例，该患者摄入9克安非他酮后出现神经毒性以及心电图显示的室内传导障碍。应考虑对这些患者进行心脏监测。
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