Glass F L, Cottam J A, Reintgen D S, Fenske N A
Medicine and Dermatopathology, USF COM, Tampa, Florida, USA.
J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):603-10. doi: 10.1016/s0190-9622(98)70010-6.
We review sentinel lymph node biopsy in patients with high-risk melanoma. This method of selective lymphadenectomy provides valuable staging information about the regional lymphatics without the need of prophylactic complete lymph node dissection. Only patients with micrometastases are candidates for complete lymph node dissection. This avoids, in nearly 85% of patients, the morbidity of the more extensive procedure. In addition, sentinel lymph node-positive patients may qualify for adjuvant therapy protocols. Whether this surgical approach ultimately results in a survival advantage awaits the results of a National Cancer Institute-sponsored national multicenter trial.
我们回顾了高危黑色素瘤患者的前哨淋巴结活检。这种选择性淋巴结切除术方法可提供有关区域淋巴管的有价值的分期信息，而无需进行预防性完全淋巴结清扫术。只有存在微转移的患者才适合进行完全淋巴结清扫术。这在近85%的患者中避免了更广泛手术带来的发病率。此外，前哨淋巴结阳性的患者可能符合辅助治疗方案的条件。这种手术方法最终是否能带来生存优势，有待美国国立癌症研究所赞助的全国多中心试验的结果。
