Steed D L
Wound Healing/Limb Preservation Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Am J Surg. 1998 Aug;176(2A Suppl):20S-25S. doi: 10.1016/s0002-9610(98)00178-0.
Diabetic foot ulcers are a significant healthcare problem affecting more than 1 million patients at some point in their lifetime. Good ulcer care begins with thorough assessment of the ulcer, which includes determining whether the ulcer is infected and whether neuropathy or peripheral vascular disease is present. The principles of good wound care include use of proper footwear, non-weight-bearing limb support, use of appropriate antibiotics, debridement, aggressive revascularization, control of serum glucose levels, and careful monitoring of the ulcer. For refractory ulcers, new therapies, such as the use of exogenous recombinant growth factors, are being developed that may have a significant benefit in treating these ulcers and lowering the amputation rate.
糖尿病足溃疡是一个重大的医疗保健问题，在其一生中的某个阶段会影响超过100万患者。良好的溃疡护理始于对溃疡的全面评估，这包括确定溃疡是否感染以及是否存在神经病变或周围血管疾病。良好伤口护理的原则包括使用合适的鞋类、非负重肢体支撑、使用适当的抗生素、清创、积极的血管重建、控制血糖水平以及仔细监测溃疡。对于难治性溃疡，正在开发新的疗法，如使用外源性重组生长因子，这可能对治疗这些溃疡和降低截肢率有显著益处。
