Kawasaki M, Funabiki R, Yagasaki K
Department of Applied Biological Science, Tokyo Noko University, Japan.
Lipids. 1998 Sep;33(9):905-11. doi: 10.1007/s11745-998-0287-6.
Abnormal lipid metabolism and its restoration by dietary methionine (Met) and cystine (Cys) were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line of AH109A. The hepatoma-bearing rats exhibited hyperlipidemia characterized by rises in serum triglyceride and cholesterol levels. Decreased lipoprotein lipase (LPL) activities in epididymal adipose tissue, cardiac muscle, and gastrocnemius as well as increased fatty acid mobilization from adipose tissue were considered to be responsible for the hepatoma-induced hypertriglyceridemia, while increased hepatic cholesterogenesis and decreased steroid excretion into feces were thought to be responsible for the hepatoma-induced hypercholesterolemia. Dietary-supplemented Met or Cys reduced the AH109A-induced hypertriglyceridemia with suppression of fatty acid synthesis in the host liver. Met restored the fall of LPL activities, while Cys did not. Dietary Met or Cys also reduced the hypercholesterolemia with restoration of decreased bile acid excretion into feces. These results suggest that dietary Met or Cys is hypolipidemic in the hepatoma-bearing rats with slight differences in their modes of action.
在皮下植入AH109A腹水肝癌细胞系的唐瑞大鼠中，研究了异常脂质代谢及其通过膳食蛋氨酸（Met）和胱氨酸（Cys）的恢复情况。荷肝癌大鼠表现出以血清甘油三酯和胆固醇水平升高为特征的高脂血症。附睾脂肪组织、心肌和腓肠肌中脂蛋白脂肪酶（LPL）活性降低以及脂肪组织中脂肪酸动员增加被认为是肝癌诱导的高甘油三酯血症的原因，而肝脏胆固醇生成增加和粪便中类固醇排泄减少被认为是肝癌诱导的高胆固醇血症的原因。膳食补充Met或Cys可降低AH109A诱导的高甘油三酯血症，并抑制宿主肝脏中的脂肪酸合成。Met恢复了LPL活性的下降，而Cys则没有。膳食Met或Cys还可降低高胆固醇血症，并恢复粪便中胆汁酸排泄的减少。这些结果表明，膳食Met或Cys在荷肝癌大鼠中具有降血脂作用，但其作用方式略有不同。
