Department of Food and Nutrition, Keimyung University, Daegu, South Korea.
Adv Exp Med Biol. 2017;975 Pt 2:1071-1080. doi: 10.1007/978-94-024-1079-2_85.
The present study was performed to know the effects of taurine on the lipid level of plasma and liver, lipid peroxidation and antioxidative enzyme activities of liver tissue in ovariectomized (OVX) rats fed cholesterol. Twenty-four female SD rats (200 ± 5 g) were grouped; sham and ovariectomy groups, which were each randomly subgrouped; fed control and control supplemented with taurine (20 g/kg diet). The serum total cholesterol, TG (triglyceride), LDL-cholesterol, athrogenic index, and HDL-cholesterol of taurine diet group were not statistically different. Also the levels of liver total cholesterol, triglyceride were not considerably different in different diets. The lipid peroxidation of malondialdehyde concentration was considerably lower in taurine-feeding group than control-feeding group in ovariectomy group. The superoxide dismutase activity in liver tissue was significantly higher in rats fed taurine than in rats fed control diet in OVX rats. GSH-Px (glutathione peroxidase) activity was statistically greater at the rats fed taurine diets compared to rats fed control diet in ovariectomy group. Activity of catalase was higher in taurine group than in control group in ovariectomy group, but it was not significantly different. In conclusion, taurine supplementation was beneficial on antioxidative enzyme activities of liver tissue in ovariectomized rats fed cholesterol.
本研究旨在探讨牛磺酸对给予胆固醇的去卵巢大鼠（OVX）血浆和肝脏脂质水平、肝组织脂质过氧化和抗氧化酶活性的影响。将 24 只雌性 SD 大鼠（200±5g）分组；假手术和去卵巢组，每组随机亚组；给予对照和对照补充牛磺酸（20g/kg 饮食）。牛磺酸饮食组的血清总胆固醇、甘油三酯（TG）、低密度脂蛋白胆固醇、动脉粥样硬化指数和高密度脂蛋白胆固醇水平无统计学差异。不同饮食中肝总胆固醇、甘油三酯水平也无显著差异。去卵巢组牛磺酸喂养组丙二醛浓度的脂质过氧化明显低于对照组。去卵巢大鼠中，牛磺酸喂养组肝组织中超氧化物歧化酶活性明显高于对照组。与对照组相比，去卵巢组牛磺酸饮食组的谷胱甘肽过氧化物酶（GSH-Px）活性更高。去卵巢组牛磺酸组的过氧化氢酶活性高于对照组，但无统计学差异。总之，牛磺酸补充对给予胆固醇的去卵巢大鼠肝组织抗氧化酶活性有益。
