Ferrier I N
University Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Neuropsychobiology. 1998 Oct;38(3):192-7. doi: 10.1159/000026536.
The anticonvulsants carbamazepine and sodium valproate have efficacy in hypomania, bipolar depression and in the prophylaxis of bipolar disorder. This paper reviews published evidence on the effects of the new anticonvulsants gabapentin and lamotrigine in bipolar disorder. The conclusion is that there is good evidence from open studies to indicate that randomised double-blind trials of these compounds should be carried out. The pharmacology of these anticonvulsants is reviewed and putative predictors of good response identified.
抗惊厥药卡马西平和丙戊酸钠在轻躁狂、双相抑郁以及双相情感障碍的预防方面具有疗效。本文综述了已发表的关于新型抗惊厥药加巴喷丁和拉莫三嗪治疗双相情感障碍效果的证据。结论是，来自开放性研究的充分证据表明，应该对这些化合物进行随机双盲试验。本文对这些抗惊厥药的药理学进行了综述，并确定了可能的良好反应预测指标。
