Lazarini C A, Vassilieff I
Departamento de Ciencias Fisiologicas, Faculdade de Medicina de Marilia, Sao Paulo, Brazil.
Vet Hum Toxicol. 1998 Oct;40(5):257-9.
Magnesium chloride (MgCl2) has been proposed for the treatment of seizures of different etiologies. The present study investigated the effect of MgCl2 on aldrin-induced seizures. Initially, 50 male rats received 60 mg aldrin/kg po and the effects were classified as muscular twitches, clonic convulsions or tonic-clonic convulsions. Another group of 40 rats dosed with 60 mg aldrin/kg po received 0, 4, 8, or 12 mg MgCl2/kg i.m. The percentage of tonic-clonic convulsant rats that resulted from MgCl2 treatment were 90% at 0 mg/kg, 50% at 4 mg/kg, 40% at 8 mg/kg and 20% at 12 mg MgCl2/kg. The percentage of survivors in the group receiving 12 mg MgCl2/kg was 80% while the control group had 20% survival. The clonic convulsions were not modified by MgCl2 treatment. Blood and brain concentrations of aldrin and dieldrin (metabolite of aldrin) did not differ among groups. The MgCl2 administration decreased the neuroexcitability induced by aldrin and increased survivability.
氯化镁（MgCl₂）已被提议用于治疗不同病因引起的癫痫发作。本研究调查了MgCl₂对艾氏剂诱发癫痫发作的影响。最初，50只雄性大鼠经口给予60 mg/kg艾氏剂，其影响被分类为肌肉抽搐、阵挛性惊厥或强直-阵挛性惊厥。另一组40只经口给予60 mg/kg艾氏剂的大鼠，分别肌肉注射0、4、8或12 mg/kg MgCl₂。MgCl₂治疗导致的强直-阵挛性惊厥大鼠百分比在0 mg/kg时为90%，4 mg/kg时为50%，8 mg/kg时为40%，12 mg/kg MgCl₂时为20%。接受12 mg/kg MgCl₂组的存活百分比为80%，而对照组的存活率为20%。MgCl₂治疗未改变阵挛性惊厥。各组间艾氏剂和狄氏剂（艾氏剂的代谢产物）的血液和脑浓度无差异。MgCl₂给药降低了艾氏剂诱导的神经兴奋性并提高了存活率。
