Schwarzenberg H
Klinik für Radiologische Diagnostik, Christian-Albrechts-Universität zu Kiel.
Rofo. 1998 Sep;169(3):227-35. doi: 10.1055/s-2007-1015083.
Since their discovery more than 60 years ago fibrinolytic agents have shown their therapeutical efficiency in myocardial infarction and other thromboembolic disorders in clinical studies. Local catheter fibrinolysis as an alternative to surgical embolectomy was established in the mid eighties. Fibrin-specific agents such as rt-PA and pulse-spray fibrinolysis as a new catheter technology were developed in order to improve the efficiency of local fibrinolysis and to minimize complications such as bleeding. The purpose of this paper is to review the historical and recent developments of fibrinolytic agents and catheter technologies, and to describe the methods, indications, and complications of local fibrinolysis.
自60多年前被发现以来，溶栓剂已在临床研究中显示出其在心肌梗死和其他血栓栓塞性疾病中的治疗效果。局部导管溶栓作为外科栓子切除术的替代方法于80年代中期确立。为了提高局部溶栓的效率并尽量减少出血等并发症，人们开发了纤维蛋白特异性药物，如rt-PA以及作为一种新导管技术的脉冲喷射溶栓。本文的目的是回顾溶栓剂和导管技术的历史及最新进展，并描述局部溶栓的方法、适应症和并发症。
