Beaumont A, Marmarou A
Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Acta Neurochir Suppl. 1998;71:149-52. doi: 10.1007/978-3-7091-6475-4_44.
Controlled cortical impact is a well validated model of cortical contusion which is known to produce cerebral edema. Corticotrophin Releasing Factor (CRF) is a hypothalamic neuropeptide, which is known to inhibit transendothelial leakage of plasma derived fluid and tissue edema in response to injury. The aim of this study was to determine cerebral edema after controlled cortical impact and then compare the effect of high and low doses of CRF. We evaluated the effect of CRF in rats divided into groups of sham, trauma alone, and trauma treated with CRF at 50 micrograms/kg and 100 micrograms/kg. Animals were sacrificed at 24 hours and water content was determined. We found that CRF was effective in reducing cerebral edema associated with cortical contusion and propose that the action of CRF obviated barrier leakage.
控制性皮质撞击是一种已得到充分验证的皮质挫伤模型，已知该模型会导致脑水肿。促肾上腺皮质激素释放因子（CRF）是一种下丘脑神经肽，已知其可抑制血浆源性液体的跨内皮渗漏以及损伤后组织水肿。本研究的目的是确定控制性皮质撞击后的脑水肿情况，然后比较高剂量和低剂量CRF的效果。我们评估了CRF对大鼠的影响，将大鼠分为假手术组、单纯创伤组以及分别用50微克/千克和100微克/千克CRF治疗的创伤组。在24小时时处死动物并测定含水量。我们发现CRF可有效减轻与皮质挫伤相关的脑水肿，并提出CRF的作用消除了屏障渗漏。
