Muccini J A, O'Donnell F E, Fuller T, Reinisch L
O'Donnell Laser Institute, St. Louis, Missouri 63122-7222, USA.
Lasers Surg Med. 1998;23(3):121-7. doi: 10.1002/(sici)1096-9101(1998)23:3<121::aid-lsm1>3.0.co;2-r.
Laser resurfacing has gained wide acceptance for the treatment of actinic facial skin. However, postoperative care of the face is reasonably complicated and prolonged erythema is common. To simplify the postoperative care and to possibly reduce the duration of the erythema, we investigated a laser treatment that spares the epithelium.
STUDY DESIGN/MATERIALS AND METHODS: A 980 nm diode laser was used with a spherical optic handpiece to focus the light in the dermis. We treated in vitro breast and facial skin and measured the tissue shrinkage and the histological changes. We also treated two patients and harvested the tissue after 6 and 21 days of wound healing.
The diode laser treatment does not ablate the epidermis. The tissue shows shrinkage (16% at 8W) similar to three passes of the scanned carbon dioxide laser treatment (15%). Thermal damage in the dermis is similar to the residual damage left after laser resurfacing with the scanned carbon dioxide laser. After 21 days the tissue shows new collagen and an abundance of young elastin fibers.
These investigations indicate that solar elastosis in skin can be treated with the 980 nm diode laser while preserving the epithelial layer.
激光换肤术已被广泛用于治疗面部光化性皮肤。然而,面部术后护理相当复杂,且持续性红斑很常见。为简化术后护理并可能缩短红斑持续时间,我们研究了一种保留上皮的激光治疗方法。
研究设计/材料与方法:使用980纳米二极管激光及球形光学手持件将光聚焦于真皮。我们对体外乳房和面部皮肤进行治疗,并测量组织收缩及组织学变化。我们还治疗了两名患者,并在伤口愈合6天和21天后采集组织。
二极管激光治疗未消融表皮。组织出现收缩(8瓦时为16%),类似于扫描二氧化碳激光治疗三遍后的收缩率(15%)。真皮的热损伤与扫描二氧化碳激光换肤后留下的残余损伤相似。21天后,组织出现新的胶原蛋白和大量年轻弹性纤维。
这些研究表明,980纳米二极管激光可在保留上皮层的同时治疗皮肤日光性弹力纤维变性。