Parrish J A, Anderson R R, Ying C Y, Pathak M A
J Invest Dermatol. 1976 Nov;67(5):603-8. doi: 10.1111/1523-1747.ep12541699.
The effects of pulsed nitrogen gas laser emission (337.1 nm wavelength) were studied on human skin. The laser provides high-intensity monochromatic UVA radiation and can elicit delayed erythema in an actual exposure time of about 1 msec (105,000 pulses, each lasting 10 nsec, delivered over 210 sec). The effects of nitrogen laser irradiation were compared clinically and histologically with conventional erythemogenic UVA and UVB exposures from xenon arc or mercury arc lamps and were found to be similar in many respects. The minimal erythema dose is comparable to that obtained using more conventional continuous light sources which have more than 100 times lower intensity. A phototoxicity comparison of oral and topically applied psoralens is presented, indicating that the laser may prove useful in comparing photosenitizing capacity of certain compounds.
研究了脉冲氮气激光发射（波长337.1纳米）对人体皮肤的影响。该激光提供高强度单色UVA辐射，在约1毫秒的实际暴露时间内（210秒内发射105,000个脉冲，每个脉冲持续10纳秒）可引发延迟性红斑。将氮气激光照射的效果与氙弧灯或汞弧灯发出的传统致红斑UVA和UVB暴露进行了临床和组织学比较，发现在许多方面相似。最小红斑剂量与使用强度低100多倍的更传统连续光源所获得的剂量相当。给出了口服和局部应用补骨脂素的光毒性比较，表明该激光可能在比较某些化合物的光敏能力方面有用。
