Dhanasekaran N, Premkumar Reddy E
Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Oncogene. 1998 Sep 17;17(11 Reviews):1447-55. doi: 10.1038/sj.onc.1202251.
Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven distinct mammalian MAP kinases kinases have been identified. Some of the unique signaling properties of these kinases are discussed here.
使丝裂原活化蛋白激酶（MAP激酶）的TXY基序中的苏氨酸和酪氨酸残基磷酸化的双重特异性激酶在细胞生长的各种过程调控中起核心作用。这些双重特异性激酶也被称为MAP激酶激酶，是连续激酶信号模块的组成部分。已鉴定出七种不同的哺乳动物MAP激酶激酶。本文讨论了这些激酶的一些独特信号特性。
