巨细胞病毒性视网膜炎与病毒耐药性：3. 培养结果。巨细胞病毒性视网膜炎与病毒耐药性研究组。

Cytomegalovirus retinitis and viral resistance: 3. Culture results. CMV Retinitis and Viral Resistance Study Group.

作者信息

Jabs D A, Enger C, Dunn J P, Forman M, Hubbard L

机构信息

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Am J Ophthalmol. 1998 Oct;126(4):543-9. doi: 10.1016/s0002-9394(98)00134-2.

DOI:10.1016/s0002-9394(98)00134-2

PMID:9780099

Abstract

PURPOSE

To evaluate the relationship between blood and urine cultures for cytomegalovirus and clinical outcomes in patients with cytomegalovirus retinitis.

METHODS

Prospective epidemiologic study of 108 patients with newly diagnosed cytomegalovirus retinitis. Blood and urine were cultured for cytomegalovirus at diagnosis of retinitis, at 1 month and 3 months after diagnosis, and every 3 months thereafter.

RESULTS

Of the patients, 80.6% were found to have either a positive blood culture or urine culture for cytomegalovirus at the time of diagnosis of retinitis, and a positive blood culture at diagnosis was associated with an increased mortality (odds ratio = 1.91, P = .012). Follow-up cultures were positive in approximately 20% of patients, and the rate was constant over time. The development of a positive blood or urine culture during follow-up correlated with the occurrence of cytomegalovirus retinitis in the contralateral eye in those patients with unilateral disease at diagnosis (odds ratio = 5.74, P = .001).

CONCLUSIONS

Patients with cytomegalovirus retinitis and positive blood cultures for cytomegalovirus have a poorer prognosis.

摘要

目的

评估巨细胞病毒性视网膜炎患者的血液和尿液巨细胞病毒培养结果与临床结局之间的关系。

方法

对108例新诊断为巨细胞病毒性视网膜炎的患者进行前瞻性流行病学研究。在视网膜炎诊断时、诊断后1个月和3个月以及此后每3个月采集血液和尿液进行巨细胞病毒培养。

结果

在视网膜炎诊断时，80.6%的患者血液或尿液巨细胞病毒培养呈阳性，诊断时血液培养阳性与死亡率增加相关（比值比=1.91，P=0.012）。约20%的患者随访培养结果呈阳性，且该比例随时间保持稳定。诊断时为单侧疾病的患者，随访期间血液或尿液培养呈阳性与对侧眼发生巨细胞病毒性视网膜炎相关（比值比=5.74，P=0.001）。