耐药肿瘤的治疗方法。
Therapeutic approach to drug resistant tumors.
作者信息
Naito M, Tsuruo T
机构信息
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
出版信息
Ther Drug Monit. 1998 Oct;20(5):577-80. doi: 10.1097/00007691-199810000-00022.
Drug resistance is a major problem in cancer chemotherapy. P-glycoprotein plays a major role in multidrug resistance in cancer cells. P-glycoprotein is expressed in some normal tissues and has physiological functions. These include protecting the brain against toxic substances at the blood-brain barrier site, excreting toxic substances from the liver, kidney, and gastrointestinal tracts, and transporting steroidal hormones in the adrenal grand. Once expressed in cancer cells. P-glycoprotein effluxes a variety of anticancer drugs, such as doxorubicin, vinca alkaloids, etoposide and taxol, and thereby allows cancer cells to show resistance to these drugs.
耐药性是癌症化疗中的一个主要问题。P-糖蛋白在癌细胞的多药耐药中起主要作用。P-糖蛋白在一些正常组织中表达并具有生理功能。这些功能包括在血脑屏障部位保护大脑免受有毒物质侵害、从肝脏、肾脏和胃肠道排泄有毒物质，以及在肾上腺中运输甾体激素。一旦在癌细胞中表达，P-糖蛋白就会排出多种抗癌药物，如阿霉素、长春花生物碱、依托泊苷和紫杉醇，从而使癌细胞对这些药物产生耐药性。
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