Loomis-Price L D, Cox J H, Mascola J R, VanCott T C, Michael N L, Fouts T R, Redfield R R, Robb M L, Wahren B, Sheppard H W, Birx D L
H.M. Jackson Foundation, Walter Reed Army Institute of Research, Rockville, MD, USA.
J Infect Dis. 1998 Nov;178(5):1306-16. doi: 10.1086/314436.
Human immunodeficiency virus (HIV)-1-infected rapid and slow progressors showed differential humoral responses against HIV envelope peptides and proteins early in infection. Sera from slow progressors reacted more strongly with short envelope peptides modeling gp160NL4-3, predominantly in gp41. Reactivity to six peptides (in constant regions C3, C4, and C5 of gp120 and in gp41) correlated with slower progression. In a novel association, reactivity to three peptides (in constant regions C1 and C3 and variable region V3 of gp120) correlated with faster progression. Envelope peptide reactivity correlated with subsequent course of disease progression as strongly as did reactivity to gag p24. Patients heterozygous for 32-bp deletions in the CCR5 coreceptor reacted more frequently to an epitope in gp41. Rapid progressors had greater gp120 native-to-denatured binding ratios than did slow progressors. While antibody-dependent cellular cytotoxicity against gp120 did not strongly differentiate the groups, slow progressors showed a broader neutralization pattern against 5 primary virus isolates.
人类免疫缺陷病毒1型（HIV-1）感染的快速进展者和缓慢进展者在感染早期对HIV包膜肽和蛋白表现出不同的体液反应。缓慢进展者的血清与模拟gp160NL4-3的短包膜肽反应更强，主要在gp41区域。对六种肽（在gp120的恒定区C3、C4和C5以及gp41中）的反应性与疾病进展较慢相关。在一个新发现的关联中，对三种肽（在gp120的恒定区C1和C3以及可变区V3中）的反应性与疾病进展较快相关。包膜肽反应性与疾病进展的后续过程的相关性与对gag p24的反应性一样强。CCR5共受体中存在32bp缺失的杂合子患者对gp41中的一个表位反应更频繁。快速进展者的gp120天然与变性结合比率高于缓慢进展者。虽然针对gp120的抗体依赖性细胞毒性不能很好地区分这两组，但缓慢进展者对5种主要病毒分离株表现出更广泛的中和模式。
