Piantadosi Anne, Panteleeff Dana, Blish Catherine A, Baeten Jared M, Jaoko Walter, McClelland R Scott, Overbaugh Julie
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
J Virol. 2009 Oct;83(19):10269-74. doi: 10.1128/JVI.01149-09. Epub 2009 Jul 29.
The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4(+) T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection.
广泛中和抗体（NAb）反应的决定因素及其对1型人类免疫缺陷病毒（HIV-1）疾病进展的影响尚未明确界定，部分原因是之前大多数关于广泛NAb反应的研究都是横断面研究。我们在一个纵向血清感染队列中，对70名未接受抗逆转录病毒治疗的肯尼亚HIV感染女性的NAb反应广度相关因素进行了研究。在感染后5年，针对五种A亚型病毒和一种B亚型病毒测量NAb反应广度。更大的NAb反应广度与感染早期更高的病毒载量设定点和更大的HIV-1 env多样性相关。然而，更大的NAb反应广度与CD4(+) T细胞计数<200的延迟时间、抗逆转录病毒治疗或死亡无关。因此，广泛的NAb反应源于感染早期高水平的抗原刺激，这可能解释了之前的观察结果，即更大的NAb反应广度与感染后期更高的病毒载量相关。
