接受粒细胞集落刺激因子治疗的艾滋病患者的中性粒细胞对鸟分枝杆菌的杀伤能力增强。

Neutrophils from AIDS patients treated with granulocyte colony-stimulating factor demonstrate enhanced killing of Mycobacterium avium.

作者信息

George S, Coffey M, Cinti S, Collins J, Brown M, Kazanjian P

机构信息

Divisions of Infectious Diseases and Pulmonary Medicine, University of Michigan Medical Center, Ann Arbor, USA.

出版信息

J Infect Dis. 1998 Nov;178(5):1530-3. doi: 10.1086/314460.

DOI:10.1086/314460

PMID:9780281

Abstract

Neutrophils isolated from AIDS patients have demonstrated improved growth inhibition of Mycobacterium avium when incubated with exogenous granulocyte colony-stimulating factor (G-CSF). In this clinical study, 30 AIDS patients without M. avium infection were randomized to receive 5 days of treatment with rifabutin, G-CSF, or both agents. The M. avium killing capacity of neutrophils harvested from each patient before intervention, during (day 4), and after therapy (day 7) was assessed. The mean change in human immunodeficiency virus load in the group receiving G-CSF alone was -0.07 log of viral RNA. There was a 90% reduction in M. avium growth after therapy for patients treated with G-CSF alone (P=.01), 59% for patients treated with both agents (P=.06), and 11% for patients treated with rifabutin alone (P=.84). Thus, neutrophils isolated from AIDS patients treated with G-CSF demonstrated a significant enhancement of killing of M. avium; there was no notable effect on virus load.

摘要

从艾滋病患者体内分离出的中性粒细胞在与外源性粒细胞集落刺激因子（G-CSF）共同孵育时，对鸟分枝杆菌的生长抑制作用有所改善。在这项临床研究中，30名未感染鸟分枝杆菌的艾滋病患者被随机分为三组，分别接受利福布汀、G-CSF或两种药物联合治疗，为期5天。评估了每位患者在干预前、治疗期间（第4天）和治疗后（第7天）采集的中性粒细胞对鸟分枝杆菌的杀伤能力。单独接受G-CSF治疗的组中，人类免疫缺陷病毒载量的平均变化为病毒RNA的-0.07对数。单独使用G-CSF治疗的患者治疗后鸟分枝杆菌生长减少了90%（P=0.01），两种药物联合治疗的患者减少了59%（P=0.06），单独使用利福布汀治疗的患者减少了11%（P=0.84）。因此，接受G-CSF治疗的艾滋病患者分离出的中性粒细胞对鸟分枝杆菌的杀伤能力显著增强；对病毒载量没有显著影响。