[Efficacy of vigabatrin associated with carbamazepine in the treatment of epilepsy. Follow up 1993-1996].

PURPOSE

To verify tolerance and clinical efficacy of vigabatrin (VGB), a new antiepileptic drug, in an add-on therapy with carbamazepine (CBZ).

PATIENTS AND METHODS

From september 1993 to december 1996, 35 patients with partial complex seizures (CPC) and CPC plus secondary generalization were treated, with VGB plus CBZ, VGB dose was 1.41 +/- 0.26 (g/die +/- SD) and CBZ 2.28 +/- 0.60 (g/die +/- SD).

RESULTS

Patients were followed-up every 4 months showing an improvement between 61.5% and 68.8% from baseline.

CONCLUSIONS

In all patients we observed an improvement during the follow-up period. Side effects were mild and well tolerated.