Bonati L, Japichino G G, Rubini P
Istituto di Clinica Chirurgica Generale e dei Trapianti d'Organo, Università degli Studi, Parma.
Minerva Chir. 1998 May;53(5):377-80.
This study reports 10 cases of uninodular bronchiolo-alveolar carcinoma (BAC) operated on in the General Surgery and Organ Transplantation Institute of the University of Parma between January 1st 1981 and December 31st 1995.
Seven patients were males and three females, mean age was 65 (DS 11, range 37-75) and globally accounted for 6.4% of all surgically treated lung malignant tumors.
Hospital mortality was null; one patient was treated with assisted ventilation four days after surgery for respiratory insufficiency. Actuarial survival at 36 and 60 months was 48% and 36% respectively; survival rates were not significantly different at log-rank test from squamous carcinoma (46.2% at 36 months, 35% at 60 months) and adenocarcinoma (50.5% at 36 months, 34.3% at 60 months). The analysis of other series of literature shows significantly higher survival rates at 5 years for BAC than for adenocarcinoma (55.6% vs 40%).
Broader series are needed for statistical confrontation with other histological types by stage and grade. There is no evidence of peculiar prognostic or clinical features in this histological type of pulmonary malignancy, prognosis so far is in fact conditioned by the same factors of other non small cell lung carcinomas.
本研究报告了1981年1月1日至1995年12月31日期间在帕尔马大学普通外科和器官移植研究所接受手术治疗的10例单结节细支气管肺泡癌（BAC）病例。
7例为男性，3例为女性，平均年龄65岁（标准差11，范围37 - 75岁），占所有手术治疗的肺恶性肿瘤的6.4%。
医院死亡率为零；1例患者术后4天因呼吸功能不全接受辅助通气治疗。36个月和60个月的精算生存率分别为48%和36%；对数秩检验显示，其生存率与鳞状细胞癌（36个月时为46.2%，60个月时为35%）和腺癌（36个月时为50.5%，60个月时为34.3%）无显著差异。对其他文献系列的分析显示，BAC的5年生存率显著高于腺癌（55.6%对40%）。
需要更大规模的病例系列，以便按分期和分级与其他组织学类型进行统计学对比。目前尚无证据表明这种组织学类型的肺恶性肿瘤具有特殊的预后或临床特征，事实上，其预后目前受其他非小细胞肺癌相同因素的制约。
