Yoshikawa T, Yoshida N, Sugimoto N, Kondo M
First Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Nihon Rinsho. 1998 Sep;56(9):2240-6.
The adherence of neutrophils to the endothelium is a crucial early event in the inflammatory and immunological reaction. Neutrophil-endothelial cell interactions are known to be mediated by adhesion molecules that are expressed on each cell. Among the adhesion molecules expressed on leukocytes, the CD11/CD18 integrin family plays a major role in the adhesion and transendothelial migration of neutrophils. The two most extensively characterized endothelial cell adhesion molecules are intercellular adhesion molecule-1 and E-selectin. These adhesion molecules are involved in the pathogenesis of several digestive diseases such as Helicobacter pylori, non steroidal anti inflammatory drug- or stress-induced gastric mucosal injury, inflammatory bowel diseases.
