Robb L, Elefanty A G
Walter and Eliza Hall Institute of Medical Research, Melbourne Hospital, Victoria, Australia.
Bioessays. 1998 Aug;20(8):611-4. doi: 10.1002/(SICI)1521-1878(199808)20:8<611::AID-BIES3>3.0.CO;2-L.
The close temporal and spatial association between blood and endothelial cell development during embryogenesis was first documented almost 100 years ago. In recent years, gene expression studies have further strengthened this link. Now, using cultures of mouse embryonic stem cells, a common progenitor cell that gives rise to both blood cells and vascular endothelial cells, has been identified. The existence of the hemangioblast has been proved and experiments addressing its unique properties can begin.
近100年前首次记录了胚胎发生过程中血液与内皮细胞发育在时间和空间上的紧密关联。近年来，基因表达研究进一步强化了这种联系。如今，利用小鼠胚胎干细胞培养物，已鉴定出一种可产生血细胞和血管内皮细胞的共同祖细胞。成血管细胞的存在已得到证实，针对其独特特性的实验也可展开。
