Shah R M, Kilistoff A
J Embryol Exp Morphol. 1976 Aug;36(1):101-8.
The effect of prenatal administration of different doses of cortisone, corticosterone, dexamethasone, triamcinolone and prednisolone on the fetus and its palatal development was studied. All the glucocorticoids, except cortisone, produced cleft palate in the fetuses. Both the total frequency and morphologically different types of cleft palate were related to the dose of the teratogen. Triamcinolone appeared to be more potent than other glucocorticoid in inducing cleft palate. An association was noted between fetal growth inhibition, the dose of the teratogen and the frequency and type of cleft palate.
研究了产前给予不同剂量的可的松、皮质酮、地塞米松、曲安西龙和泼尼松龙对胎儿及其腭部发育的影响。除可的松外，所有糖皮质激素均导致胎儿腭裂。腭裂的总发生率和形态不同类型均与致畸剂剂量有关。曲安西龙在诱导腭裂方面似乎比其他糖皮质激素更具效力。观察到胎儿生长抑制、致畸剂剂量与腭裂的发生率和类型之间存在关联。
