Polymerase chain reaction analysis of the Y chromosome long arm in azoospermic patients: lack of the Y chromosome recognition motif (YRRM1) gene.
作者信息
Baba K, Iwamoto T, Nakagome Y, Kuroki Y, Nakahori Y, Yajima M, Tanaka H, Osada T
机构信息
Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
出版信息
Int J Urol. 1998 Sep;5(5):507-9. doi: 10.1111/j.1442-2042.1998.tb00403.x.
Abstract
We analyzed DNA from a patient with azoospermia whose Y chromosome was cytogenetically normal. A total of 16 loci on the Y chromosome long arm were examined: 15 loci between DYS7E and DYZ1, and the Y chromosome RNA recognition motif (YRRM1) locus, a candidate gene for the azoospermic factor AZF. We did not detect the YRRM1 gene in this patient. This finding supports the theory that YRRM1 is an essential gene for spermatogenesis.
摘要
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