Schlienger R G, Knowles S R, Shear N H
Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, ONT, Canada.
Neurology. 1998 Oct;51(4):1172-5. doi: 10.1212/wnl.51.4.1172.
We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with lamotrigine are comparable to AHS induced by older aromatic anticonvulsants.
我们系统地回顾并分析了已发表和未发表的与抗惊厥药超敏反应综合征（AHS）特征相符的拉莫三嗪相关药物不良反应病例，以确定该综合征的特征。我们识别出26例病例（平均年龄28±18岁；范围3.5至74岁；54%为女性），其中9例已发表。与拉莫三嗪相关的该综合征特征与 older芳香族抗惊厥药诱发的AHS相当。
