Leigh B R, Lau D H
Department of Radiation Oncology, University of California, Davis Cancer Center, Sacramento 95817-2229, USA.
Am J Clin Oncol. 1998 Oct;21(5):479-81. doi: 10.1097/00000421-199810000-00012.
This case report documents severe esophagitis and rapid esophageal stricture formation in a man infected with the human immunodeficiency virus (HIV) who was treated with standard thoracic irradiation for locally advanced non-small-cell lung cancer. Severe late esophageal toxicity is a rare complication of radiation therapy in patients who are HIV negative, but those who are HIV positive may be at increased risk. This article reviews the literature suggesting that HIV infection may lead to unusually severe radiation-induced mucosal injury. High-dose chest irradiation should be performed with caution in this group of patients.
本病例报告记录了一名感染人类免疫缺陷病毒（HIV）的男性患者，在接受标准胸部放疗以治疗局部晚期非小细胞肺癌后，发生了严重食管炎和快速食管狭窄形成。严重的晚期食管毒性在HIV阴性患者中是放疗罕见的并发症，但HIV阳性患者可能风险更高。本文回顾了相关文献，提示HIV感染可能导致异常严重的放射性黏膜损伤。对这组患者进行高剂量胸部放疗时应谨慎。
