ⅩⅥ型胶原蛋白的表达受碱性成纤维细胞生长因子和转化生长因子-β的调节。
Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor-beta.
作者信息
Grässel S, Tan E M, Timpl R, Chu M L
机构信息
Dept. of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
出版信息
FEBS Lett. 1998 Oct 2;436(2):197-201. doi: 10.1016/s0014-5793(98)01122-3.
We investigated the effects of bFGF and TGF-beta on the expression of type XVI collagen, a member of the fibril associated collagen family, in human dermal fibroblasts and arterial smooth muscle cells. We found that bFGF decreased the alpha1(XVI) collagen mRNA to 18-24% of the controls, while TGF-beta increased the mRNA to 150-360%. Immunoprecipitation of metabolically labeled cells revealed corresponding, but less pronounced, changes at the protein levels. The results suggested that type XVI collagen expression is regulated by bFGF and TGF-beta in a manner similar to their regulation of the major type I fibrillar collagen produced by these cells.
我们研究了碱性成纤维细胞生长因子（bFGF）和转化生长因子-β（TGF-β）对人皮肤成纤维细胞和动脉平滑肌细胞中ⅩⅥ型胶原蛋白（原纤维相关胶原蛋白家族的一员）表达的影响。我们发现，bFGF可使α1（ⅩⅥ）胶原蛋白mRNA降至对照组的18%-24%，而TGF-β可使该mRNA增加至150%-360%。对代谢标记细胞进行免疫沉淀显示，蛋白质水平上有相应但不太明显的变化。结果表明，ⅩⅥ型胶原蛋白的表达受bFGF和TGF-β的调控，其调控方式类似于它们对这些细胞产生的主要Ⅰ型纤维状胶原蛋白的调控。
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