Tarasidis G, Watanabe O, Mackinnon S E, Strasberg S R, Haughey B H, Hunter D A
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Otolaryngol Head Neck Surg. 1998 Oct;119(4):337-41. doi: 10.1016/S0194-5998(98)70074-9.
This study evaluated long-term reinnervation of an end-to-side neurorraphy and the resultant functional recovery in a rat model. The divided distal posterior tibial nerve was repaired to the side of an intact peroneal nerve. Control groups included a cut-and-repair of the posterior tibial nerve and an end-to-end repair of the peroneal nerve to the posterior tibial nerve. Evaluations included walking-track analysis, nerve conduction studies, muscle mass measurements, retrograde nerve tracing, and histologic evaluation. Walking tracks indicated poor recovery of posterior tibial nerve function in the experimental group. No significant difference in nerve conduction velocities was seen between the experimental and control groups. Gastrocnemius muscle mass measurements revealed no functional recovery in the experimental group. Similarly, retrograde nerve tracing revealed minimal motor neuron staining in the experimental group. However, some sensory staining was seen within the dorsal root ganglia of the end-to-side group. Histologic study revealed minimal myelinated axonal regeneration in the experimental group as compared with findings in the other groups. These results suggest that predominantly sensory regeneration occurs in an end-to-side neurorraphy at an end point of 6 months.
本研究在大鼠模型中评估了端侧神经吻合术的长期再支配情况及由此产生的功能恢复。将切断的胫后神经远端修复到完整的腓总神经侧面。对照组包括胫后神经切断并修复以及腓总神经与胫后神经的端端修复。评估包括行走轨迹分析、神经传导研究、肌肉质量测量、逆行神经追踪和组织学评估。行走轨迹表明实验组胫后神经功能恢复较差。实验组和对照组之间神经传导速度未见显著差异。腓肠肌质量测量显示实验组无功能恢复。同样，逆行神经追踪显示实验组运动神经元染色极少。然而，在端侧组的背根神经节内可见一些感觉染色。组织学研究显示，与其他组的结果相比，实验组有髓轴突再生极少。这些结果表明，在6个月的终点时，端侧神经吻合术中主要发生感觉再生。
