Thomassin J M, Epron J P, Régis J, Delsanti C, Sarabian A, Peragut J C, Pellet W
Federation of Oto-neurosurgery, CHU TIMONE, Marseille, France.
Stereotact Funct Neurosurg. 1998 Oct;70 Suppl 1:74-9. doi: 10.1159/000056409.
138 acoustic schwannomas were treated by Gamma Knife surgery from July 1992 to May 1994. Cases with neurofibromatosis were excluded because of differences in the patterns of growth and development of tumors in these cases. Hearing was evaluated by tonal and vocal audiometry and classified using the Gardner and Robertson score. 104 patients were observed at 3 years after treatment. Hearing studies, the relation of tumor volume to hearing, central and marginal dose, number of shots and preoperative brain-stem-evoked responses (BER) were all recorded. 70% of patients with normal hearing maintained a useful hearing, and 50% of patients with useful hearing maintained serviceable hearing. No correlation was found between hearing preservation and tumor volume, central and marginal dose and number of shots. Gamma Knife surgery seems to be superior to microsurgery with regard to preservation of useful hearing.
1992年7月至1994年5月期间，138例听神经鞘瘤接受了伽玛刀手术治疗。患有神经纤维瘤病的病例被排除在外，因为这些病例的肿瘤生长和发展模式存在差异。通过纯音听力计和声导抗测听法评估听力，并使用加德纳和罗伯逊评分进行分类。治疗后3年对104例患者进行了观察。记录了听力研究、肿瘤体积与听力的关系、中心和边缘剂量、照射次数以及术前脑干诱发电位（BER）。70%听力正常的患者保持了有用听力，50%有用听力的患者保持了可用听力。在听力保留与肿瘤体积、中心和边缘剂量以及照射次数之间未发现相关性。在保留有用听力方面，伽玛刀手术似乎优于显微手术。
