Servent D, Thanh H L, Antil S, Bertrand D, Corringer P J, Changeux J P, Ménez A
Département d'Ingénierie et d'Etudes des Proteines, CEA-Saclay, Gif-sur-Yvette, France.
J Physiol Paris. 1998 Apr;92(2):107-11. doi: 10.1016/s0928-4257(98)80146-0.
Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.
蛇和芋螺会产生毒素，这些毒素会阻断肌肉和/或神经元烟碱型乙酰胆碱受体（AChRs）。本文主要聚焦于蛇的长链箭毒样毒素和芋螺毒素ImI特异性结合α7神经元受体的决定因素。在这两种情况下，结合位点都涉及一个由两个半胱氨酸限制的类似小转角的结构。
