与神经递质释放相关的蛋白质相互作用。

Protein interactions implicated in neurotransmitter release.

作者信息

el Far O, O'Connor V, Dresbach T, Pellegrini L, DeBello W, Schweizer F, Augustine G, Heuss C, Schäfer T, Charlton M P, Betz H

机构信息

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.

出版信息

J Physiol Paris. 1998 Apr;92(2):129-33. doi: 10.1016/S0928-4257(98)80150-2.

DOI:10.1016/S0928-4257(98)80150-2

PMID:9782456

Abstract

Biochemical evidence indicates that the exocytotic release of neurotransmitters involves both evolutionary conserved membrane proteins, the SNAREs, as well as ubiquitous cytosolic fusion proteins, NSF and SNAPs. We have analyzed the biochemical properties and the physiological effects of these proteins. Our data suggest models how NSF, SNAPs and SNAREs may function in neurotransmitter exocytosis.

摘要

生化证据表明，神经递质的胞吐释放涉及进化上保守的膜蛋白SNAREs，以及普遍存在的胞质融合蛋白NSF和SNAPs。我们分析了这些蛋白的生化特性和生理效应。我们的数据提出了NSF、SNAPs和SNAREs可能在神经递质胞吐过程中发挥作用的模型。