Rendina E A, Venuta F, De Giacomo T, Guarino E, Ciccone A M, Quattrucci S, Della Rocca G, Antonelli M, Ricci C, Coloni G F
Department of Thoracic Surgery, University of Rome, La Sapienza, Italy.
Eur J Pediatr Surg. 1998 Aug;8(4):208-11. doi: 10.1055/s-2008-1071155.
Between November 1996 and November 1997 we have transplanted 13 patients with Cystic Fibrosis (CF). Bilateral Sequential Lung Transplantation (BSLT) was successfully performed in all patients; one patient died from pneumonia and sepsis in the postoperative period and 12 are alive and well after a follow-up ranging between 1 and 13 months. Blood gas analysis improved from mean values of PaO2: 56 mm/Hg (with oxygen) and PaCO2: 43 mm/Hg to mean values of PaO2: 85 mm/Hg and PaCO2: 37 mm/Hg. Pulmonary function tests also improved dramatically: FEV1 improved from 20% predicted to 98% predicted. FVC also improved from 39% to 100%. The quality of life markedly improved: the ideal body weight moved from about 84% to normal values within nine months, and the 6-minute walk-test improved after transplantation from a preoperative distance of 325 meters, to 600 meters after 6 months. In conclusion, our favorable experience with BSLT in CF patients emphasizes the importance of lung transplantation in these patients. Carefully selected and properly managed patients may benefit from transplantation in terms of quality and duration of life.
1996年11月至1997年11月期间，我们为13例囊性纤维化（CF）患者进行了移植手术。所有患者均成功接受了双侧序贯肺移植（BSLT）；1例患者术后死于肺炎和败血症，12例患者在1至13个月的随访后存活且状况良好。血气分析结果从平均PaO2：56 mmHg（吸氧时）和PaCO2：43 mmHg改善至平均PaO2：85 mmHg和PaCO2：37 mmHg。肺功能测试也显著改善：第一秒用力呼气容积（FEV1）从预计值的20%提高到98%。用力肺活量（FVC）也从39%提高到100%。生活质量明显改善：理想体重在9个月内从约84%恢复到正常水平，6分钟步行试验在移植后从术前的325米改善到6个月后的600米。总之，我们在CF患者中进行BSLT的良好经验强调了肺移植对这些患者的重要性。经过精心挑选和妥善管理的患者在生活质量和寿命方面可能会从移植中受益。
