Shliakhtenko L I, Mukomolov S L, Nechaev V V, Kryga L N
Pasteur Research Institute of Epidemiology and Microbiology, Mechnikov Medical Academy, St. Petersburg, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 1998 Jul-Aug(4):25-9.
In this article the development of the concepts concerning the sources of hepatitis B virus in the second half of the XXth century is analyzed and the importance of patients with manifest and latent forms of chronic infection as the main reservoir of the infective agent is substantiated. The scheme of the mechanisms and paths of the transmission of hepatitis B virus is proposed, the mechanism of transmission understood only as the natural ways of the spread of the infective agent which result from its evolutionary development and can be only slightly controlled at present. The study revealed that the present decrease of morbidity rate is greatly determined by measures of the social character, aimed at the elimination of the artificial paths of virus transmission.
本文分析了20世纪下半叶有关乙型肝炎病毒来源概念的发展,并证实了显性和潜伏性慢性感染患者作为传染源主要储存库的重要性。提出了乙型肝炎病毒传播机制和途径的示意图,传播机制仅被理解为传染源自然传播方式,这是其进化发展的结果,目前只能略微加以控制。研究表明,目前发病率的下降在很大程度上取决于社会层面的措施,这些措施旨在消除病毒传播的人为途径。