纤维蛋白封闭剂敷料在肾损伤动物模型中的止血效果。
Hemostatic efficacy of a fibrin sealant dressing in an animal model of kidney injury.
作者信息
Jackson M R, Taher M M, Burge J R, Krishnamurti C, Reid T J, Alving B M
机构信息
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9157, USA.
出版信息
J Trauma. 1998 Oct;45(4):662-5. doi: 10.1097/00005373-199810000-00003.
OBJECTIVE
The purpose of this study is to determine the hemostatic efficacy of a fibrin sealant dressing compared with a standard collagen control dressing in an animal model of kidney injury.
METHODS
Twenty adult male Sprague-Dawley rats were administered general anesthesia and underwent partial nephrectomy with heparin anticoagulation (300 U/kg intravenous). Treatment of the cut surface of the kidney was randomized to three groups: group I, no hemostatic agent; group II, collagen dressing; and group III, fibrin sealant dressing.
RESULTS
Blood loss was significantly less in group III (3.39+/-0.63 mL) than in group I (8.64+/-2.26 mL) and group II (8.63+/-1.72 mL; p < 0.001). The percentage decrease in the mean arterial pressure was significantly less in group III (34.09+/-15.58%) than in group I (59.66+/-16.19%) and group II (60.35+/-15.66%; p=0.015).
CONCLUSION
Fibrin sealant dressings provide effective hemostasis and are superior to collagen dressings in an animal model of kidney injury. Additional development of fibrin sealant dressings for potential clinical use is warranted.
目的
本研究旨在确定在肾损伤动物模型中，纤维蛋白密封剂敷料与标准胶原蛋白对照敷料相比的止血效果。
方法
对20只成年雄性Sprague-Dawley大鼠实施全身麻醉，并在肝素抗凝（300 U/kg静脉注射）下进行部分肾切除术。肾脏切面的处理随机分为三组：第一组，不使用止血剂；第二组，胶原蛋白敷料；第三组，纤维蛋白密封剂敷料。
结果
第三组（3.39±0.63 mL）的失血量显著少于第一组（8.64±2.26 mL）和第二组（8.63±1.72 mL；p<0.001）。第三组平均动脉压的下降百分比（34.09±15.58%）显著低于第一组（59.66±16.19%）和第二组（60.35±15.66%；p=0.015）。
结论
在肾损伤动物模型中，纤维蛋白密封剂敷料能有效止血，且优于胶原蛋白敷料。有必要进一步开发纤维蛋白密封剂敷料以供临床使用。
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