Fleck C, Langner B
Institute of Pharmacology and Toxicology, Friedrich Schiller University of Jena, Germany.
Exp Toxicol Pathol. 1998 Sep;50(4-6):432-9. doi: 10.1016/S0940-2993(98)80030-4.
In adult female anaesthetized rats, the influence of triiodothyronine or dexamethasone on renal amino acid (AA) handling was investigated in taurine (45 mg/100 g b.wt.) loaded animals. Bolus injections of taurine were followed by temporary increase in fractional excretion (FE(AA)) of taurine as well of the endogenous amino acids which were not administered. Under taurine load conditions, triiodothyronine treatment (20 microg/100 g b.wt. for 3 days, i.p. once daily) was followed by a slight stimulation of the renal taurine reabsorption: the increase in FE(taurine) after taurine load was lower than in untreated rats. Dexamethasone (60 microg/100 g b.wt. for 3 days, i.p. once daily) was without significant effect on FE(taurine) in taurine loaded rats. In non taurine loaded rats there was no hormone influence at all. Similarities and differences between the effects of bolus injections of taurine, glutamine, and leucine on the FE(AA) of these three amino acids were compared in detail to further clarify the reason for the increased amino acid reabsorption capacity after pretreatment with triiodothyronine or dexamethasone.
在成年雌性麻醉大鼠中，研究了三碘甲状腺原氨酸或地塞米松对预先负荷牛磺酸（45毫克/100克体重）的动物肾脏氨基酸（AA）处理的影响。静脉推注牛磺酸后，牛磺酸以及未给予的内源性氨基酸的分数排泄（FE(AA)）暂时增加。在牛磺酸负荷条件下，三碘甲状腺原氨酸治疗（20微克/100克体重，连续3天，每天腹腔注射一次）后，肾脏对牛磺酸的重吸收略有刺激：牛磺酸负荷后FE(牛磺酸)的增加低于未治疗的大鼠。地塞米松（60微克/100克体重，连续3天，每天腹腔注射一次）对牛磺酸负荷大鼠的FE(牛磺酸)没有显著影响。在未负荷牛磺酸的大鼠中，完全没有激素影响。详细比较了静脉推注牛磺酸、谷氨酰胺和亮氨酸对这三种氨基酸FE(AA)的影响的异同，以进一步阐明用三碘甲状腺原氨酸或地塞米松预处理后氨基酸重吸收能力增加的原因。
