Szayna M, Kuhn W
BCL, Sunnyvale, CA 94088-1154, USA.
J Eur Acad Dermatol Venereol. 1998 Sep;11(2):122-8.
Data obtained from in vivo and in vitro measurements on human skin and skin samples are presented.
In vivo measurements, using a 3-Tesla magnetic resonance system, on the forearm of three female volunteers show an increase of signal intensity, after application of cream, between 30% and 58%, depending on the cream type. In-plane resolution was 90 microm, with slice thickness of 2 mm. Chemical-shift-selective in vitro microimaging studies were performed on a 9.4-T spectrometer using human skin samples from the abdomen. In these experiments, in-plane resolution was 4 microm and slice thickness was 100 microm.
The results demonstrate clearly the moisturising effect of beauty care products on the stratum corneum, which can be identified in in vitro experiments. No ingress into the skin of the lipid components of the emulsions could be observed in vitro. However, skin occlusion and consequently a long-lasting moisturising effect cannot be excluded.
These results prove the capability of magnetic resonance imaging to investigate human skin in vivo and in vitro, and to follow the skin penetration of beauty-care products and pharmaceutical ointments.
展示从人体皮肤及皮肤样本的体内和体外测量中获得的数据。
使用3特斯拉磁共振系统对三名女性志愿者的前臂进行体内测量，结果显示，涂抹面霜后，信号强度增加了30%至58%，具体增幅取决于面霜类型。平面分辨率为90微米，切片厚度为2毫米。使用取自腹部的人体皮肤样本，在9.4特斯拉光谱仪上进行化学位移选择性体外显微成像研究。在这些实验中，平面分辨率为4微米，切片厚度为100微米。
结果清楚地证明了美容护理产品对角质层的保湿效果，这在体外实验中可以得到证实。在体外未观察到乳液的脂质成分进入皮肤。然而，不能排除皮肤闭塞以及由此产生的持久保湿效果。
这些结果证明了磁共振成像能够在体内和体外研究人体皮肤，并追踪美容护理产品和药膏的皮肤渗透情况。
