落叶型天疱疮患者中针对桥粒斑蛋白的抗体。
Antibodies to desmoplakin in a patient with pemphigus foliaceous.
作者信息
Jiao D, Bystryn J C
机构信息
Ronald O. Perelman Department of Dermatology, New York University Medical Center, NY 10016, USA.
出版信息
J Eur Acad Dermatol Venereol. 1998 Sep;11(2):169-72.
BACKGROUND
Antibodies to desmoplakins have been associated with paraneoplastic pemphigus. Here, we report a case of non-neoplastic pemphigus foliaceous with antibodies to desmoplakins.
OBSERVATION
A 61-year-old woman with pemphigus foliaceous by clinical, histological and immunofluorescent criteria was found to have circulating antibodies to 250 and 215 kDa antigens identified as desmoplakin I and II by immunoblotting and immunoprecipitation. The patient had no evidence of cancer during a follow-up period of 3 years.
CONCLUSION
Although antibodies to desmoplakin I and II have previously been associated with paraneoplastic pemphigus, their occasional finding in erythema multiforme and bullous pemphigoid indicates that they can also occur in non-neoplastic pemphigus.
背景
桥粒斑蛋白抗体与副肿瘤性天疱疮相关。在此，我们报告一例具有桥粒斑蛋白抗体的非肿瘤性落叶型天疱疮病例。
观察
一名61岁女性，根据临床、组织学和免疫荧光标准诊断为落叶型天疱疮，通过免疫印迹和免疫沉淀法发现其循环抗体针对250 kDa和215 kDa抗原，经鉴定为桥粒斑蛋白I和II。在3年的随访期内，该患者无癌症证据。
结论
尽管桥粒斑蛋白I和II抗体以前与副肿瘤性天疱疮相关，但其偶尔在多形红斑和大疱性类天疱疮中出现表明它们也可发生于非肿瘤性天疱疮。
Zotero 插件