Hall F S, Huang S, Fong G W, Pert A, Linnoila M
Laboratory of Clinical Studies, National Institutes on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892, USA.
Psychopharmacology (Berl). 1998 Oct;139(3):203-9. doi: 10.1007/s002130050705.
Voluntary ethanol (EtOH) consumption is increased by isolation-rearing in several rat strains. The following experiments examined the effects of isolation-rearing on basal and ethanol-stimulated behavior in Fawn Hooded rats, an alcohol-preferring rat strain, compared to Wistar rats. Locomotor activity and anxiety were examined under both conditions. Basal locomotor activity was higher in isolated subjects of both strains in low light conditions, but under bright light conditions, this difference was only observed in Wistar rats. Locomotor stimulant effects of EtOH were only observed in isolation-reared rats. In the elevated plus maze, Fawn Hooded rats were more anxious than Wistar rats under low light conditions, but under bright light conditions, Wistar socials were less anxious than all of the other groups. Administration of 1.5 mg/kg EtOH produced an anxiolytic response in the elevated plus maze under bright light conditions in Fawn Hooded rats, but to a lesser degree Wistar rats, particularly Wistar isolates. In conclusion, although both strain and isolation-rearing had effects on locomotion and anxiety as well as the stimulatory and anxiolytic effects of EtOH, these effects appeared to be independent.
在几种大鼠品系中，隔离饲养会增加乙醇（EtOH）的自愿摄入量。以下实验研究了与Wistar大鼠相比，隔离饲养对嗜酒大鼠品系小鹿帽鼠的基础行为和乙醇刺激行为的影响。在两种条件下均检测了运动活性和焦虑水平。在低光照条件下，两个品系的隔离饲养大鼠的基础运动活性均较高，但在明亮光照条件下，这种差异仅在Wistar大鼠中观察到。乙醇对运动的刺激作用仅在隔离饲养的大鼠中观察到。在高架十字迷宫实验中，在低光照条件下，小鹿帽鼠比Wistar大鼠更焦虑，但在明亮光照条件下，Wistar群居大鼠比其他所有组的大鼠焦虑程度更低。在明亮光照条件下，给小鹿帽鼠腹腔注射1.5 mg/kg乙醇可在高架十字迷宫实验中产生抗焦虑反应，但Wistar大鼠，尤其是Wistar隔离饲养大鼠的抗焦虑反应程度较小。总之，尽管品系和隔离饲养对运动、焦虑以及乙醇的刺激和抗焦虑作用均有影响，但这些影响似乎是相互独立的。
