Hanna S, Dzus G, Rasero L, Lachman L
J Pharm Sci. 1976 Oct;65(10):1552-5. doi: 10.1002/jps.2600651026.
An automated procedure was developed for the determination of warfarin sodium by following the steps of the manual USP procedure. The automated procedure is applicable to single tablets and composites of 20 tablets at different tablet concentrations. Sensitivity, precision, accuracy, and reproducibility are equivalent to the manual USP procedure. Sensitivity was approximately 15 mug/ml, with a coefficient of variation of 0.711%.
通过遵循美国药典手动程序的步骤，开发了一种用于测定华法林钠的自动化程序。该自动化程序适用于不同片剂浓度的单片片剂和20片片剂的组合。灵敏度、精密度、准确度和重现性与美国药典手动程序相当。灵敏度约为15微克/毫升，变异系数为0.711%。
