p53蛋白过表达：子宫浆液性乳头状癌的一个强有力的预后因素。

p53 protein overexpression: a strong prognostic factor in uterine papillary serous carcinoma.

作者信息

Bancher-Todesca D, Gitsch G, Williams K E, Kohlberger P, Neunteufel W, Obermair A, Heinze G, Breitenecker G, Hacker N F

机构信息

Gynecopathology Unit, Department of Medical Computer Sciences, University Hospital of Vienna, Währinger Gürtel 18-20, Vienna, A-1090, Austria.

出版信息

Gynecol Oncol. 1998 Oct;71(1):59-63. doi: 10.1006/gyno.1998.5113.

DOI:10.1006/gyno.1998.5113

PMID:9784320

Abstract

Uterine papillary serous carcinoma (UPSC) is an uncommon but aggressive type of endometrial cancer associated with rapid progression of disease and poor prognosis. We investigated 23 cases of UPSC. p53 expression was studied in archival paraffin-embedded tissue by immunohistochemistry. Eleven tumors (47.8%) showed p53 overexpression whereas 12 tumors (52.2%) were p53 negative. One of 8 stage I/II (12.5%) and 10/15 stage III/IV (66.6%) tumors revealed p53 staining (P = 0.027). The median overall survival was 43.3 months. Patients with advanced-stage (III, IV) disease had a 5-year overall survival probability (5-year OS%) of 24% compared to 100% in those in stages I and II (log-rank, P = 0.018). Myometrial invasion, lymphatic space invasion, or lymph node involvement did not correlate with the 5-year OS of these patients. Patients whose tumors overexpressed p53 had a significantly shorter survival than those whose tumors did not (P = 0.033). This study confirms the influence of p53 overexpression on survival in UPSC patients.

摘要

子宫浆液性乳头状癌（UPSC）是一种罕见但侵袭性强的子宫内膜癌，与疾病快速进展和预后不良相关。我们研究了23例UPSC病例。通过免疫组织化学方法在存档石蜡包埋组织中研究p53表达。11例肿瘤（47.8%）显示p53过表达，而12例肿瘤（52.2%）为p53阴性。8例I/II期肿瘤中的1例（12.5%）和15例III/IV期肿瘤中的10例（66.6%）显示p53染色（P = 0.027）。总生存期的中位数为43.3个月。晚期（III、IV期）疾病患者的5年总生存概率（5年OS%）为24%，而I期和II期患者为100%（对数秩检验，P = 0.018）。肌层浸润、淋巴管浸润或淋巴结受累与这些患者的5年总生存期无关。肿瘤过表达p53的患者生存期明显短于肿瘤未过表达p53的患者（P = 0.033）。本研究证实了p53过表达对UPSC患者生存的影响。