Zografi G, Tam S S
J Pharm Sci. 1976 Aug;65(8):1145-9. doi: 10.1002/jps.2600650805.
Contact angle measurements of water and methylene iodide with various organic solids were used to estimate the surface free energy per square centimeter, gammaS, and the contributions of nonpolar and polar forces, gammaSd and gammaSp, respectively. The ratio of gammaSp to gammaS was used as an estimate of solid surface polarity, and values ranging from 0 to 42% polarity were calculated for materials of pharmaceutical interest. Surface free energies per mole were calculated to compare the influence of different substituent groups on wettability. This approach offers a convenient means to quantitate the polarity of organic pharmaceutical solid surfaces.
通过测量水和二碘甲烷与各种有机固体的接触角，来估算每平方厘米的表面自由能γS，以及非极性力和极性力的贡献，分别为γSd和γSp。γSp与γS的比值被用作固体表面极性的估算值，对于具有药学意义的材料，计算出的极性值范围为0至42%。计算每摩尔的表面自由能，以比较不同取代基对润湿性的影响。这种方法提供了一种方便的手段来定量有机药物固体表面的极性。
